The Upper Michigan Brain Tumor Center Research Lab is located on the campus of Northern Michigan University. The focus of our lab is oncomodulation. That is, we are investigating genetic, molecular and viral factors that make glioblastoma more resistant to treatment, more likely to recur, and better able to evade the immune system. Additionally, our lab is committed to preparing our undergraduate and graduate students for careers in medicine and biomedical research.
[learn_more caption=”Recent Publications”] Cook NJ, Lawrence JE, Rovin RA, Belton RJ, Winn RJ. Effects of ß3-adrenergic receptor agonist on gene expression of leptin in glioblastoma. Neuro-Oncology. 14(suppl 6):vi7-vi20, 2012.
Sabin KZ, Rovin RA, Lawrence JE, Belton RJ, Winn RJ. Glioblastoma Derived Exosomes Induce Apoptosis in Cytotoxic T Cells Through a Fas Ligand Mediated Mechanism. Neurosurgery. Aug;71(2):E574, 2012.
Lawrence JE, Cook NJ, Rovin RA, Winn RJ. Leptin Promotes Glioblastoma. Neurol Res Int. 2012:870807, 2012.
Lawrence JE, Cook NJ, Rovin RA, Winn RJ. β3-adrenergic agonists mimic eustress response and reduce leptin-mediated proliferation in a GBM cell line. Neuro-Oncology. 13 (Suppl 3):iii1-iii167, 2011.
Sabin KZ, Lebert D, Thibado V, Rovin RA, Lawrence JE, Winn RJ. Glioblastoma derived exosomes contribute to tumor immune evasion. Neuro-Oncology. 13 (Suppl 3):iii1-iii167, 2011.[/learn_more]
[learn_more caption=”Recent Presentations”] 2012
Glioblastoma Derived Exosomes Induce Apoptosis in Cytotoxic T Cells Through a Fas Ligand Mediated Mechanism. Oral Presentation at the Congress of Neurological Surgeons Annual Meeting, Chicago, IL, October 6-10, 2012.
Effects of ß3-adrenergic receptor agonist on gene expression of leptin in glioblastoma. Poster at the Society for Neuro-Oncology Annual Meeting, Washington, DC, November 15-18, 2012.
2011
Development and Early Experience with an iPhone App for Sideline Concussion Testing. Poster at the Congress of Neurosurgical Surgeons Annual Meeting, October 1-6, 2011, Washington DC.
PARP-1 Inhibition Enhances the Cytotoxic Effects of Temozolomide in Glioblastoma Cell Lines. Poster at the Congress of Neurosurgical Surgeons Annual Meeting, October 1-6, 2011, Washington DC.
β3-Adreneric Agonists Mimic Eustress Response and Reduce Leptin-Mediated Proliferation in a GBM Cell Line. Poster at the Society of Neuro-Oncology Annual Meeting, November 17-20 2011, Orange County CA.
Glioblastoma Derived Exosomes Contribute To Tumor Immune Evasion. Poster at the Society of Neuro-Oncology Annual Meeting, November 17-20 2011, Orange County CA.
Effects of 1,α-Dihydroxyvitamin D3 on Cultured Glioblastoma Multiforme Cells. Poster at the Annual Biomedical Research Conference for Minority Students (ABRCMS) November 2011 St. Louis, MO.
2010
The Human Cytomegalovirus Protein IE1 Confers Resistance to Temozolomide in the U87MG Cell Line. Accepted at the 9th International Meeting, Updates in Neuro Oncology, Brain Tumor Symposium, July 2-4, 2010, Cortona, Italy.
Increasing Resistant Glioblastoma Multiforme Sensitivity to Temozolomide: Silencing and Inhibition of MGMT and PARP-1. Poster at the 18th International Conference on ADP-ribose Metabolism, August 18-21, 2010 Zurich, Switzerland.
The Human Cytomegalovirus Protein IE1 Confers Resistance to Temozolomide in the U87MG Cell Line. Poster at the Congress of Neurological Surgeons Annual Meeting, October 17-21, 2010, San Francisco, CA.
The Human Cytomegalovirus Protein IE1 Confers Resistance to Temozolomide in the U87MG Cell Line. Poster at the Society of Neuro Oncology Annual Meeting, November 18-21, 2010, Montreal, Canada.
2008
MGMT Silencing using RNA Interference Renders Human Malignant Glioma Cell Lines More Sensitive to Temozolomide. ePoster at the 76th American Association of Neurological Surgeons Meeting, April 26-May 1, 2008, Chicago, IL.
Development of a Rapid RT-PCR Assay for MGMT Expression. Poster at the Congress of Neurological Surgeons Annual Meeting, September 20-25, 2008, Orlando, FL.
2007
ZBTB7 Expression in Malignant Glioma. ePoster at the AANS/CNS Section on Tumors Meeting, April 13-14, 2007, Washington, DC.
MGMT Expression and Temozolomide Response in a Patient with a Malignant Spinal Cord Astrocytoma—Case Report. ePoster at the AANS/CNS Section on Tumors Meeting, April 13-14, 2007, Washington, DC.
ZBTB7 Expression in Malignant Glioma. Presented at the 75th American Association of Neurological Surgeons Meeting, April 15-19, 2007, Washington, DC. (The BrainLab Community Neurosurgery Research Award Presentation).
Temozolomide in Addition to Gliadel Wafer and Radiotherapy in Adults with Newly Diagnosed Glioblastoma Multiforme. The Impact of MGMT Expression. Accepted at the Annual Meeting of the Neurosurgical Society of America, June 3-6, 2007, Kohler, WI.
MGMT Expression and Temozolomide Response in a Patient with a Malignant Spinal Cord Astrocytoma. Accepted at the Annual Meeting of the Neurosurgical Society of America, June 3-6, 2007, Kohler, WI.
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