Research Update



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Our book chapter, Targeting DNA Repair Mechanisms to Treat Glioblastoma, should be published any day  in  a new book called DNA Repair. Stay tuned for the the link.

1-20-2014
New research led by H.S. Student Ashish Patel and U Student Christopher Steele sheds new light on fluorescence guided resection of brain tumors. This work was published in a recent issue of ISRN Surgery.

NewFigure1-CellPic
Confocal images of PpIX fluorescence (a), YFP fluorescence (b), and the overlay (c) of both for U87-YFP cells treated with 0.4mM 5-ALA for 2 hours.

2-13-12. Laser confocal microscope used to image GBM on a molecular level. In the photomicrograph below, the blue color is the nucleus of the cell. The bright green dots are Gli1, a cancer causing protein. The role of Gli1, the hedgehog pathway and vitamin D in GBM is the subject of Justine Pinskey’s Master’s Thesis

U87 glioblastoma cells seen through the confocal microscope. Photo by Justine Pinskey
10-20-2011
The hormone leptin more has been shown to augment tumor growth in a variety of cancers. We wrote a review paper, co-authored by undergraduate student Nick Cook, outlining the leptin’s role in GBM.

Leptin_Review_Final_Figure1

8-9-11. Yellow fluorescent protein successfully transfected into U87 human glioblastoma cell line, by undergraduate student Christopher Steele!